Methadone Clinics in Greenville, SC

Looking for methadone clinics in Greenville? 4 of the city's 18 listed providers offer it.

What to know

Methadone for opioid use disorder can only be dispensed by a federally certified opioid treatment program (OTP). Most patients visit daily at first, then earn take-home doses as treatment goes on.

Chart: 4 of 18 treatment facilities in Greenville, SC offer methadone — Methadone Clinics in Greenville: share of local facilities and the South Carolina average.

Methadone: 4 facilities

Crossroads Treatment Centers

157 Brozzini Court, Greenville, SC 29615

OutpatientMATMethadone (OTP)MedicaidMedicarePrivate insuranceTRICARE / VA

Call (800) 805-6989 Details

Greenville Metro Treatment Center

602 Airport Road, Greenville, SC 29607

OutpatientIntensive outpatientMATMethadone (OTP)MedicaidMedicarePrivate insuranceTRICARE / VA

Details

Crossroads Treatment Center of Greenville, PC

157 Brozzini Court, Greenville, SC 29615

MATMethadone (OTP)

Call (864) 288-7636 Details

Greenville Metro Treatment Center

602 Airport Rd., Greenville, SC 29609

MATMethadone (OTP)

Call (864) 234-7952 Details

Questions

How many methadone clinics are in Greenville?

We list 4 facilities in Greenville, SC reporting methadone services. Call ahead to confirm availability and wait times.

How do I choose between them?

Ask each facility whether they are licensed by South Carolina, whether they accept your insurance or Medicaid, how soon they can admit you, and whether they offer medication for opioid or alcohol use disorder.

Last reviewed 2026-10-06. Facility details come from SAMHSA's FindTreatment.gov locator and facility-provided information. Confirm services, availability and payment directly with the facility.